Serotonergic 5-HT3 receptors in the central nervous system are involved in pain processing
after nerve injury. We are interested in learning if 5-HT3 receptor antagonist ondansetron
might be an appropriate drug for treating pain after nerve injury (neuropathic pain), by
investigating its bio-distribution in the cerebro-spinal fluid, and the genetic variability
that may affect that distribution.
Study procedures will include iv ondansetron administration, serial blood draws,
cerebrospinal fluid (CSF) sampling, pregnancy testing, and possible ECG.