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You can access this
clinical trial
if you have
Neonatal Thrombocytopenia Isoimmunization Maternal-fetal
and you are
over 18
years old
-
The phase for this study is not defined.
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The purpose

Neonatal thrombocytopenia isoimmunization maternal-fetal is related to maternal immunization against fetal platelet antigens with paternal origin not present in the mother. It is considered the equivalent of hemolytic disease of the newborn. The incidence of this disease is about 1 in 800-1000 births. The most severe forms associated petechiae, purpura or cephalhematoma at birth with a major risk of cerebral hemorrhages (20% to 25% of cases) can cause the death of the child (15%) or severe neurological troubles (15-30%) Biologic diagnosis requires the detection of anti-platelet antibodies with maternal determination of platelet phenotypes and genotypes of the two parents. The objective of this work is to develop specific molecular tools to fetal platelet genotyping from maternal blood. We are particularly interested to antigens HPA-1, HPA-5 , HPA-3 and HPA-4. We evaluate the sensitivity and specificity of this test by comparing these results with those obtained from an invasive sampling of amniotic fluid. This is a prospective study to assess the technical and diagnostic performance of a new molecular method noninvasive prenatal diagnosis of platelet genotyping.

Provided treatments

  • Biological: Extra blood draw samples
  • Biological: extra amniotic fluid samples

Locations near you

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Tris trial is registered with FDA with number: NCT02899598. The sponsor of the trial is Assistance Publique Hopitaux De Marseille and it is looking for 48 volunteers for the current phase.
Official trial title: