HIV-infected patients with intermediate-high risk have a high prevalence of CAD and a
substantial proportion of obstructive CAD. Degree of stenosis is associated with
immunoactivation (lymphocyte and monocyte) and microbial translocation
Biological: blood test
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Full eligibility criteria for NCT02898896
Ages eligible for Study
48 Years to 100 Years
Genders eligible for Study
Accepts Healthy Volunteers
HIV-infected patients >= 45 years with 2 or more CV risk factors currently on ART HIV-RNA < 50 copies >= 12 months (one blip allowed) Asymptomatic regarding cardiac symptoms (chest pain, syncope, dyspnea) Stable ART for more than 6 months
Previous CV event (MI, stroke, unstable angina, CABG) Atrial fibrillation Chronic kidney disease [eGFR < 60ml/min MDRD or CKD-Epi) Unstable liver disease History of IV contrast allergy Chronic inflammatory disorders apart from HIV
All locations for NCT02898896
Montpellier, France, 34295
View full eligibility
Tris trial is registered with FDA with number: NCT02898896. The sponsor of the trial is University Hospital, Montpellier and it is looking for 62 volunteers for the current phase.
Official trial title: Asymptomatic Obstructive Coronary Artery Disease (CAD) in Suppressed HIV-infected Patients ≥ 45 Years and 2 or More CV Risk Factors. Associations With Persistent Immune Activation and Microbial Translocation
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