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Community-based Early Stage Lung Cancer Screening With Low-dose Computed Tomography in China (NCT02898441)

The present study is a randomized controlled trial of LDCT screening for lung cancer versus usual care. 6000 high-risk subjects (age 45-70) were recruited and randomized to the Active arm (Baseline + 2 biennial repeated LDCT screening) or to the Passive arm, followed up in usual care (Baseline + 2 biennial repeated questionnaire inquiries). Follow-up for lung cancer incidence, lung cancer mortality and overall mortality was performed. Blood samples were stored from the Active arm in a Biobank. Management of positive screening test was carried out by a pre-specified protocol.
  • Device: Low Dose Computed Tomography
    LDCT were performed in screening arm. The abnormal nodules were defined as noncalcified nodules (NCN) larger than 4 mm.
    Ages eligible for Study
    45 Years to 70 Years
    Genders eligible for Study
    Accepts Healthy Volunteers
    Accepts Healthy Volunteers
    Inclusion Criteria:
    • Eligible participants were those aged 45-70 years, and with either of the following risk factors:
    • history of cigarette smoking ≥ 20 pack-years, and, if former smokers, had quit within the previous 15 years;
    • malignant tumors history in immediate family members;
    • personal cancer history;
    • professional exposure to carcinogens;
    • long term exposure to second-hand smoke;
    • long term exposure to cooking oil fumes.
    Exclusion Criteria:
    • Had a CT scan of chest within last 12 months
    • History of any cancer within 5 years

    1 locations

    China (1)
    • Shanghai Chest hospital
      Shanghai, Shanghai, China, 200030
    31 December, 2013
    07 September, 2016
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