• Overview
  • Eligibility
  • More info
  • Locations

Transcutaneous Oxygen as a Predictor of Wound Healing Complications in Preoperatively Radiated Soft Tissue Sarcoma (NCT02897128)

University of Florida
University of Iowa
University of Oklahoma
Medical University of South Carolina
The University of Texas Health Science Center at San Antonio
Musculoskeletal Tumor Society
Loyola University Chicago
Wound complications after sarcoma resection are frequent and potentially devastating problem. The burden of surgical wound complications in the lower extremity after preoperative external beam radiation therapy (EBRT) for soft tissue sarcoma is estimated at 43%. A noninvasive method of predicting complications would be extremely beneficial. The aim of this study is to evaluate the relationship between preoperative skin oxygenation and wound outcomes in a multi-center prospective analysis. This information could lead to a change in practice regarding surgical timing and adjunctive interventions to improve wound healing outcomes.
  • Other: Observational Only - Transcutaneous Oxygen Measurement
    The transcutaneous oxygen at your surgical site will be measured at three time points prior to your surgery.
    Ages eligible for Study
    18 Years and older
    Genders eligible for Study
    All
    Accepts Healthy Volunteers
    No
    Inclusion Criteria:
    • age > 18
    • biopsy proven soft tissue sarcoma of the lower extremity (pelvic area and below)
    • plan for preoperative radiation and limb sparing resection
    Exclusion Criteria:
    • upper extremity sarcoma
    • recurrent soft tissue sarcoma
    • prior surgery in the area of the sarcoma
    • prior radiation in the area of the sarcoma
    • need for immediate skin graft or flap for coverage
    • pregnant patients
    • patients unwilling to have surgery or radiation
    It is estimated that there are 11,400 new cases of soft tissue sarcoma diagnosed in the United States annually. Most high-grade sarcomas, and other selected low or intermediate grade sarcomas, are treated with a limb salvage surgical resection in conjunction with external beam radiation to optimize local control. The current preference of most practicing orthopaedic/surgical oncologists and radiation oncologists is to implement the radiation treatments prior to surgery to diminish the total radiation dose and field size, thereby optimizing long-term functional results of the salvaged limb. While there are clear advantages of preoperative radiation, there are well-demonstrated negative consequences with regard to healing of the surgical wound. Currently there are no reliable clinical criteria to aid physicians in determining an individual patient's risk of developing a postoperative wound complication. This fact, combined with the rarity of the sarcoma diagnosis, has prevented improvement in wound outcomes in sarcoma patients.

    This project is designed to close this critical gap in knowledge. The investigators propose utilizing a preoperative measurement of transcutaneous oxygen (Tc02) at the proposed incision to classify patients into high- and low-risk categories for development of wound complications after resection. Measurement of preoperative TcO2 represents a novel application of a simple, noninvasive method by which to assess skin oxygenation. Given the results of an already completed pilot investigation (Nystrom 2016), the investigators believe that this important clinical problem is well suited for a prospective, multi-disciplinary, multi-institutional investigation.

    A successful project would result in an enhanced ability to identify wounds at risk prior to surgery and allow for additional investigation into perioperative interventions (delay of surgery until recovery of oxygenation, increasing suture duration, judicious use of muscle flaps and skin grafts, postoperative hyperbaric oxygen, or treatment with incisional wound vacuum-assisted closure) that may mitigate this significant adverse outcome.

    7 locations

    United States (7)
    • University of Florida
      not yet recruiting
      Gainesville, Florida, United States, 32611
    • Loyola University Medical Center
      not yet recruiting
      Maywood, Illinois, United States, 60153
    • University of Iowa Hospitals and Clinics
      recruiting
      Iowa City, Iowa, United States, 52242
    • Cleveland Clinic
      recruiting
      Cleveland, Ohio, United States, 44195
    • University of Oklahoma
      not yet recruiting
      Oklahoma City, Oklahoma, United States, 73104
    • Medical University of South Carolina
      not yet recruiting
      Charleston, South Carolina, United States, 29425
    • University of Texas Health and Science Center San Antonio
      not yet recruiting
      San Antonio, Texas, United States, 78229
    Status:
    recruiting
    Type:
    Observational
    Phase:
    -
    Start:
    30 June, 2016
    Updated:
    25 September, 2017
    Participants:
    60
    Apply
    A girl giving information about available additional trials.

    FindMeCure helps you find, understand and join clinical trials from all over the world.

    There are more clinical trials for your condition!