Vancomycin is a glycopeptide antibiotic that is the first line antibiotics for the treatment
of serious gram-positive infections involving methicillin-resistant Staphylococcus aureus
(MRSA). Its therapeutic window is narrow, so there is a need to monitor serum vancomycin
concentration in clinical practice, especially in the critically ill patients. So far, few
studies have investigated the clinical outcomes of the dosage strategy that vancomycin dosage
is administered and adjusted individually using PPK and Bayesian methods based on observed
concentrations. The objective of this study is to investigate the effectiveness, safety and
economics of the vancomycin individualized dosing service provided by pharmacists.