Beta-lactam antibiotics include penicillin and cephalosporins and are among the most
prescribed antibiotics. This category of drugs is the most involved in immediate allergic
manifestations with 2% reactions in treated subjects and a fatal outcome in 1/50000
treatments. Reactions are IgE-mediated and have a considerable but unknown genetic origin,
revealed by studies in groups of different ethnical origins in the same geographical region.
There are also some families with a high frequency of allergic reactions without identified
The purpose of this study is to identify predictive risk factors associated to immediate
allergic reactions against beta-lactam antibiotics with a pangenomic approach.
A secondary purpose is to identify rare predictive factors with homozygosity mapping and
exome sequencing in various families with high risk of allergy to beta-lactam antibiotics.