Kidney Failure, Chronic
Johns Hopkins Bloomberg School of Public Health
This pilot study will be a clinical trial to test the feasibility and effectiveness of a kidney transplant (KT) prehabilitation intervention in adults with end stage renal disease (ESRD) who are within 3-6 months of transplantation.
- Other: PrehabilitationThe study will use a generic prehabilitation program which will include the following components: Warm-up, cardiovascular training, strength training, flexibility training, and cool down. Prehabilitation will occur once per week and approximately 1 hour in duration. Participants will take part in prehabilitation until they receive a kidney transplant which by study design is approximately for 3-6 months.
- exercise training
|Ages eligible for Study||18 Years and older|
|Genders eligible for Study||All|
|Accepts Healthy Volunteers||No|
- Men and women with end stage renal disease who are within 3-6 months of kidney transplantation and are on the kidney transplant waitlist at Johns Hopkins
- Must be at least 18 years or older at enrollment
- Must be English speaking
- Must be enrolled in an ongoing cohort study of adults with ESRD who are being evaluated for kidney transplantation
- Must be willing to participate in a prehabilitation program and able to give informed consent
- Patients who have any of the following medical conditions will be excluded from the study:
- Active Angina pectoris
- Chronic lung disease and daily use of oxygen
- Cerebral vascular disease
- Musculoskeletal conditions that would limit participation in prehabilitation
- Lower- or upper-extremity amputation
- Orthopedic disorders exacerbated by physical activity
- Decreased mental capacity
- Patients who live outside of Maryland will not be included in the study.
Prehabilitation is the enhancement of functional capacity of a patient to improve their ability to withstand a future stressor. The investigators primary objective is to demonstrate feasibility for prehabilitation in Aim 1 and test whether the number of prehabilitation sessions is associated with increased physical activity. The investigators will formally test whether prehabilitation is associated with a reduction in short term and long term KT outcomes as part of Aim 2. The investigators will test whether there is an effect of prehabilitation on short-term (KT length of stay> 2 weeks, early hospital readmission and delayed graft function) and long-term (acute rejection (within the first year), 1 year patient and graft survival) outcomes compared to standard of care controls. Participants will be followed for 3-6 months or until they receive a kidney transplant.
United States (1)
- Johns Hopkins Physical Medicine and RehabilitationNot specifiedLutherville, Maryland, United States, 21093
enrolling by invitation
31 May, 2016
05 September, 2016