Stroke treatment includes thrombolysis, thrombectomy for patients with proximal artery
occlusion and sometimes neurosurgery. It rises questions regarding hemostasis: thrombolysis
induces fibrinolysis but its effects on coagulation, fibrinogen and platelets and duration of
these effects are unknown. Thus management of antithrombotics and hemostasis during
thrombectomy and surgery is an issue.
Objectives : to describe thrombolysis-induced hemostatic disorders (fibrinolysis,
coagulation, fibrinogen, platelets) in patients requiring thrombectomy for stroke and to
evaluate the time required for the normalization of these disorders.
Methods : Observational monocentric study including rtPA-treated patients requiring
endovascular treatment for stroke. Blood sampling within the first 48 hours after rtPA
administration to assess of fibrinolysis, coagulation and platelet functions with point of
care devices and specific laboratory tests. Record of clinical and biological data.