This trial is completed!
Search for a recruiting clinical trial for your condition
Your journey
1What's a trial
4Get in touch
More info
You can access this
clinical trial
if you have
Prevalence of Germs, Spinal Surgery, Anterior Disc Disease or Modic 1
and you are
between 18 and 75
years old
This is an observational trial.
You are contributing to medical knowledge about your condition.
Show me locations

The purpose

Low back pain is one of the most frequent reasons for consultation in rheumatology. There is a strong correlation between low back pain, and the presence of a type of Modic 1 signal on MRI. The anomaly Modic 1 results in a hypointense signal T1-weighted images and hyperintense on T2-weighted sequences (including T2 STIR and / or Fat Sat) and contrast enhancement of the endplates after gadolinium injection; it corresponds to a replacement of normal cancellous bone of fibrovascular tissue. The origin of this inflammatory process Modic 1 into the vertebra is still unknown. infectious hypothesis was raised, including contamination by germs called "slow-growth" such as Propionibacterium acnes (PA). Many studies interesting Bacteriological analysis of disc material found the presence of bacteria (prevalence between 0 and 54%). A recent clinical trial evaluating the efficacy of antibiotic treatment compared to placebo in low back pain with Modic 1; a show effectiveness of this treatment on the different clinical parameters evaluated. However skin contamination is not formally excluded, particularly in patients previously infiltrated (including epidural). Our hypothesis is that the slow-growing bacteria are not involved in Modic 1 type of disc disease, and the possible presence of PA or other slow-growing bacteria in samples obtained discal posterior approach would be related to intraoperative contamination or during preoperative spinal infiltrations The main objective is to assess the prevalence of germs slow growth in the intervertebral disc in the spinal surgery by anterior disc disease in type 1 Modic.

Provided treatments

  • Other: Bacteriological analysis of disc

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT02892617. The sponsor of the trial is Assistance Publique - Hôpitaux de Paris and it is looking for 80 volunteers for the current phase.
Official trial title:
Evaluation of the Prevalence of Germs Slow Growth in the Intervertebral Disc (IVD) During Spinal Surgery: a Single-center Prospective Observational Study