This study will evaluate the performance of Alloderm RTU medium (LifeCell) vs. Cortiva 1mm
Allograft Dermis (RTI Surgical®, Inc.). These are the thinnest versions of acellular dermal
matrices (ADM) offered by both vendors and can be used for post-mastectomy breast
reconstruction. Alloderm RTU medium has a thickness of 1.6±0.4 mm, while Cortiva 1mm
Allograft Dermis has a thickness of 1.0±0.2 mm. In the context of breast reconstruction,
these ADMs are used in the same manner. They may be inserted with a tissue expander
immediately after skin- or nipple-sparing mastectomy. The investigators will examine
breast-reconstruction associated complication rates, pre- and post-operative patient reported
outcomes using the Breast Q, and physician reimbursement as well as direct hospital costs.
The endpoint will be either exchange of the tissue expander for a permanent breast implant or
autologous flap, explantation due to patient preference, development of a complication, or
less common reasons. The investigators propose that Cortiva 1mm Allograft Dermis and Alloderm
RTU will have equivalent complication and patient reported outcome rates as well as physician
reimbursement, but that direct hospital cost will be less with Cortiva 1mm Allograft Dermis.