To evaluate antihypertensive effect and safety of CS-3150 compared to Eplerenone in patients
with essential hypertension.
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Full eligibility criteria for NCT02890173
Ages eligible for Study
20 Years and older
Genders eligible for Study
Accepts Healthy Volunteers
Male and female subjects aged 20 years or older at informed consent
Subjects with essential hypertension satisfying the following blood pressure criteria;
Sitting SBP: ≥ 140 mmHg and < 180 mmHg
Sitting DBP: ≥ 90 mmHg and < 110 mmHg
Mean 24 hr BP: SBP ≥ 130 and DBP ≥ 80 mmHg
Secondary hypertension or malignant hypertension
Diabetic nephropathy or diabetes mellitus with albuminuria
Serum potassium level < 3.5 or ≥ 5.1 mEq/L
Reversed day-night life cycle including overnight workers
eGFR < 60 mL/min/1.73 m^2
All locations for NCT02890173
Sapporo, Hokkaido, Japan
View full eligibility
Tris trial is registered with FDA with number: NCT02890173. The sponsor of the trial is Daiichi Sankyo Co., Ltd. and it is looking for 1001 volunteers for the current phase.
Official trial title: A Double Blind Study of CS-3150 to Evaluate Efficacy and Safety Compared to Eplerenone in Patients With Essential Hypertension (ESAX-HTN Study)
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