The rates of patients with spontaneous pregnancies reported after breast cancer is between 3
and 7%, particularly because of these treatments.
Therefore, it is essential to anticipate this problem by proposing the use of fertility
preservation techniques for these young patients prior to any gonadotoxic treatment.
PRESAGE study offers to patients fewer than 40, to preserve their fertility before
neoadjuvant or adjuvant chemotherapy for invasive breast cancer.
The aim of this study is to evaluate the feasibility of ovarian stimulation emergency order
not to delay the start of treatment. This stimulation combined gonadotropin and tamoxifen
followed by an oocyte retrieval. The patient may receive an oocyte vitrification and / or
This procedure is already done in many countries, and by some French teams, by combining
tamoxifen or letrozole to the classic gonadotropin stimulation.