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More info
You can access this
clinical trial
if you have
Breast Cancer
and you are
between 18 and 40
years old
This is a second phase trial assessing
efficacy and side effects of the new treatment.
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The purpose

The rates of patients with spontaneous pregnancies reported after breast cancer is between 3 and 7%, particularly because of these treatments. Therefore, it is essential to anticipate this problem by proposing the use of fertility preservation techniques for these young patients prior to any gonadotoxic treatment. PRESAGE study offers to patients fewer than 40, to preserve their fertility before neoadjuvant or adjuvant chemotherapy for invasive breast cancer. The aim of this study is to evaluate the feasibility of ovarian stimulation emergency order not to delay the start of treatment. This stimulation combined gonadotropin and tamoxifen followed by an oocyte retrieval. The patient may receive an oocyte vitrification and / or embryonic. This procedure is already done in many countries, and by some French teams, by combining tamoxifen or letrozole to the classic gonadotropin stimulation.

Provided treatments

  • Drug: Tamoxifen stim in early follicular phase
  • Drug: Tamoxifen stim in late follicular phase
  • Drug: Tamoxifen stim in luteal phase

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT02890082. The sponsor of the trial is Institut Cancerologie de l'Ouest and it is looking for 102 volunteers for the current phase.
Official trial title:
Pilot Study of Preservation of Fertility by Ovarian Stimulation Associated With Tamoxifen, and Freezing Oocyte or Embryo Prior Chemotherapy for Breast Cancer