Working hypothesis: the interactions between the endogenous endocannabinoïds (ECS) - and
cortisol, the end product of the Hypothalamo-Pituitary-Adrenal (HPA) axis may play a role in
the pathophysiology of Cushing's syndrome.
The investigators speculate that:
- acute or chronic variations in plasma cortisol may induce changes in the activity of the
- that there is a circadian rhythm of the ECS driven by the rythm of plasma cortisol