The purpose is to study the correlation between systemic inflammation (serum levels of CRP,
IL-1beta, IL-6 and TNF-alpha) or hyperhomocysteinemia and the increase of mortality, in a
representative cohort of patients with chronic obstructive pulmonary disease (COPD).
Secondary purposes are:
1. To confirm the increase of cardiovascular mortality and the importance of cardiovascular
morbidity in patients with COPD,
2. To establish the role of various genetic polymorphisms in the correlation between
systemic inflammation and cardiovascular disorders observed in COPD,
3. To search for acceleration of aging of cardiovascular system evaluated with carotid
intima-media thickness when systemic inflammation markers are increased,
4. To study the correlation between COPD risk factors (tobacco and other food factors),
change of respiratory functional data and cardiovascular morbi-mortality. In this study
cardiovascular morbi-mortality is defined by following disorders: ischemic cardiopathy,
left-sided heart failure, cardiac arrhythmia and cerebrovascular accident. Diagnosis is
confirmed with standard techniques and independently of this study. Results of clinical
examination, ECG, echocardiography and /or brain scanner will be collected.