It is proposed to carry out the study in three medical or surgical intensive care units (ICU)
in the CHRU, Lille, and the CHU, Besançon. In all patients admitted to these ICU (see Figure
2), a corrected index of colonisation (CIC) will be determined and blood samples will be
taken for genotyping of the lectins MBL, Dectin-1 and Galectin-3 and for serology. Over the
duration of hospitalisation (on average 28 days) and weekly, fungal colonisation will be
assessed in all patients (according to the CIC), and antibodies to yeast glycans will be
determined by a simultaneous multiparametric analysis involving several families of natural
or synthetic antigens, and the detection of circulating antigens (mannan and β-1,3 glucan).