The para-aortic lymph node involvement in the advanced stage of cervical cancer is a poor
prognostic factor for overall survival. Concomitant chemo-radiotherapy has become the
standard treatment for advanced cervical cancer. In case of para-aortic lymph node
involvement, an extension of radiotherapy fields is recommended.
A prospective multicentre study shown that the survival rate of patients with node ≤ 5 mm and
which benefited from the expansion of radiotherapy fields was identical to the survival of
However, due to a specific disease, this technique should not be performed in all patients.
It is necessary to reliably select patients with retroperitoneal lymph node involvement. For
this, it is recommended that prior to the concurrent chemo-radiotherapy, nodal staging
surgery with a definitive histological analysis.
So we propose to use molecular diagnostic test OSNA (One Step Nucleic Acid Amplification) to
improve lymph node metastasis detection sensitivity to achieve ultra-staging compared to