The study has two objectives:
1. To obtain endoscopic and colonoscopic biopsies to harvest and culture intestinal crypts
from human tissue to produce organoids. These organoids will be used to study the
biology of innervated sensory epithelial cells.
2. to collect subject data relating to clinical management and demographic characteristics
of patients undergoing upper endoscopy or colonoscopy to learn the mechanisms behind
visceral hypersensitivity, and neurodegenerative diseases that may arise in the gut.