The purpose of this study is to determine whether deep neuromuscular blockade provides better
surgical conditions than moderate neuromuscular blockade in patients undergoing vocal cord
resections requiring jet ventilation.
Drug: Rocuronium bromide 0.5 mg/kg
Drug: Rocuronium bromide 1.0 mg/kg
Drug: Sugammadex sodium 2 mg/kg
Drug: Sugammadex sodium 4 mg/kg
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Full eligibility criteria for NCT02888067
Ages eligible for Study
18 Years and older
Genders eligible for Study
Accepts Healthy Volunteers
Elective vocal cord resection with an expected length of the procedure longer than 20
minutes and requiring jet ventilation
Patients younger than 18 years old
Patients unable to give written informed consent
Patients with known or suspected neuromuscular disease
Patients with allergies to medications to be used during anesthesia
Patients with a (family) history of malignant hyperthermia
Patients with renal insufficiency (serum creatinine >2 times normal or a glomerular
filtration rate <60 ml/h)
All locations for NCT02888067
Montreal, Quebec, Canada, H4A3J1
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Tris trial is registered with FDA with number: NCT02888067. The sponsor of the trial is Thomas Schricker and it is looking for 30 volunteers for the current phase.
Official trial title: Surgical Conditions During Vocal Cord Surgery Requiring Jet Ventilation in Patients With Moderate vs. Deep Neuromuscular Block
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