Preoperative 5FU based chemoradiotherapy is still the standard of treatment for locally
advanced rectal cancer. About 15-20% of patients would achieve pathologic complete response
(pCR) after neoadjuvant CRT, and the survival outcome was much better than that of non-pCR.
Total neoadjuvant treatment had been evaluated a lot in recent years, including induction
chemotherapy or consolidation chemotherapy, or concurrent chemoradiotherapy. We aimed to
evaluated the safety and efficacy of total neoadjuvant treatemnt in locally advanced rectal