The NFPTR was established in 1994 to find the causes of pancreatic cancer. In brief, the
investigators are interested in both the genetic and non-genetic causes of pancreatic cancer.
The investigators are particularly interested in finding the genes that cause pancreatic
cancer to cluster in some families. Up to 10% of pancreatic cancer patients have another
close relative who has also developed pancreatic cancer. This clustering of pancreatic
cancers in families has yet to be explained; however, the investigators continue to identify
new familial pancreatic cancer genes that explain this clustering in subsets of families. For
example, in 2009 and 2012 the investigators discovered that mutations in the PALB2 and ATM
genes jointly account up to 5% of the clustering of pancreatic cancer in families.