Osteoarthritis is a degenerative disease of hyaline cartilage not associated with an
infection or an inflammatory process that affects millions of people. The first symptoms
usually appear from 40-50 years and at this point, conventional radiological tests provide
diagnostic elements relatively late, poorly correlated with pain relief and providing no
functional information. In this context, there is a real need for imaging techniques for
early detection of osteoarthritic changes in a still reversible stage for faster support and
MRI appears to be the tool of choice.
Conventional proton MRI sequences already allow improved detection possibilities compared to
conventional radiology and CT arthrography supplanted. They nevertheless remain insufficient
to identify incipient lesions or paradoxically to the point of too advanced lesions. Due to
recent technological advances, exploration MRI other nuclei such as sodium is now possible.
Quantitation of sodium in the cartilage by sodium MRI allow quantifying proteoglycan loss and
ultimately a gradation osteoarthritic reached.
This project's main objective is to quantify the biochemical changes (sodium content)
occurring at different stages of osteoarthritis defined by clinical algofunctional scores
(Lequesne) and conventional radiographic scores (Kellgren and Lawrence).