The purpose of this study is to determine whether dopamine synthesis capacity by using [18
fluorine(F)]-DOPA PET for patients with schizophrenia in the maintenance phase can predict
Behavioral: clinical scale
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Full eligibility criteria for NCT02884518
Ages eligible for Study
19 Years to 45 Years
Genders eligible for Study
Accepts Healthy Volunteers
Patients who met DSM-IV criteria for schizophrenia, schizoaffective disorder, and schizophreniform disorder
patients diagnosed with first episode psychosis which occurred within 2 years and having been treated with antipsychotics for at least 1 year.
Patients who have maintained in the stable state for 3 months without medication change at the baseline.
Healthy control group
Healthy controls has no Axis I disorder and do not report any past event of neurological or psychiatric illness assessed by the Structured Clinical Interview for DSM Disorders
Participants should not have any neurological illness such as head trauma, seizure and meningitis.
Participants should not be diagnosed as Mental retardation(IQ<70)
Participants should not have severe personality disorder, substance abuse or dependence (except for nicotine abuse and dependence) and severe medical conditions.
Tris trial is registered with FDA with number: NCT02884518. The sponsor of the trial is Seoul National University Hospital and it is looking for 35 volunteers for the current phase.
Official trial title: Predicting Successful Antipsychotic Discontinuation in the First Episode Psychosis by Using Positron Emission Tomography(PET) withPositron Emission Tomography With 3,4-dihydroxy-6-18-fluoro-l-phenylalanine ([18 Fluorine(F)]DOPA)
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