E2 given in late luteal phase can be extended beyond the onset of menses for a period of at
least eight days before the start of the stimulation, allowing scheduling of stimulation in
order to limit oocytes retrievals during weekends .
Administration of corifollitropin alfa, a Follicule stimulating Hormone (FSH) with extended
release kinetics, seems particularly interesting for a synchronous recruitment of follicles
after homogenization of the cohort.
The objective of this study is to evaluate the impact on the response to ovarian stimulation
with corifollitropin alfa of E2 scheduling versus no scheduling for women over 38 years, age
at which declining of ovarian reserve usually begins. The management of these patients in
terms of organization of the center is also evaluated.
The scheduling of IVF cycles represents a double benefit. On one hand, to enable a
"synchronization" of the follicular cohort for a best response and a higher number of mature
oocytes. On the other hand, a more efficient organization for both the center (avoiding
retrievals on weekends and public holidays, organize and distribute equally the activity,
reduce cost operations) and couples (personal and professional organization).