The utility of conventional imaging in the development of new treatments for osteoarthritis
(OA) is hindered by:
1. Difficulty in non-invasively evaluating the initial response to potential new treatment
options. OA typically develops over a long time period, so evaluating the efficacy of
new treatment options over a timeframe relevant to experimental medicine studies is
2. Inadequate methods of disease quantification and stratification. OA is a heterogeneous
condition and identifying which subgroups of patients are most likely to benefit from
new treatments is crucial.
Novel magnetic resonance (MR) imaging acquisition and analysis techniques have the potential
to solve these problems. However, their reliability needs to be fully established and
knowledge of likely effect sizes is required to inform sample size considerations for further
This study aims to help address these issues by:
1. Calculating effect sizes for MR measurements to inform sample size calculations for
2. Assessing the reliability of a multiparametric MR protocol for assessment of the knee
The investigators will examine a single knee of an initial 15 participants with MR.
Participants will be drawn from two groups: (1) 10 participants aged 40-60 years old with
clinical and x-ray features of OA and (2) 5 control subjects (matched to cases for age, sex
and body mass index in a 1:2 ratio) who do not have clinical features of OA.
Participants will undergo an initial (baseline) MR examination, followed by repeat MR
examinations at approximately 1 month and 1 year following the baseline examination.
This will allow us to assess both the reliability of our MR measurements and the expected
progression in our MR measurements in OA subjects in the absence of any disease-modifying