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More info
You can access this
clinical trial
if you have
B Acute Lymphoblastic Leukemia, Central Nervous System Leukemia, Ph-Like Acute Lymphoblastic Leukemia or Testicular Leukemia
and you are
between 1 and 31
years old
3
This is a trial in the final phase before the treatment is released on the market.
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The purpose

This randomized phase III trial studies how well combination chemotherapy works in treating young patients with newly diagnosed B acute lymphoblastic leukemia that is likely to come back or spread, and in patients with Philadelphia chromosome (Ph)-like tyrosine kinase inhibitor (TKI) sensitive mutations. Chemotherapy drugs, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) and giving the drugs in different doses and in different combinations may kill more cancer cells.

Provided treatments

  • Drug: Clofarabine
  • Drug: Cyclophosphamide
  • Drug: Cytarabine
  • Drug: Dasatinib
  • Drug: Daunorubicin Hydrochloride
  • Drug: Dexamethasone
  • Drug: Doxorubicin Hydrochloride
  • Drug: Etoposide
  • Drug: Hydrocortisone Sodium Succinate
  • Other: Laboratory Biomarker Analysis
  • Drug: Leucovorin Calcium
  • Drug: Mercaptopurine
  • Drug: Methotrexate
  • Drug: Pegaspargase
  • Drug: Prednisone
  • Radiation: Radiation Therapy
  • Drug: Thioguanine
  • Drug: Vincristine Sulfate

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT02883049. The sponsor of the trial is National Cancer Institute (NCI) and it is looking for 5956 volunteers for the current phase.
Official trial title:
A Phase III Randomized Trial for Newly Diagnosed High Risk B-Lymphoblastic Leukemia (B-ALL) Including a Stratum Evaluating Dasatinib (NSC#732517) in Patients With Ph-like Tyrosine Kinase Inhibitor (TKI) Sensitive Mutations