Neonatal hypoxic-ischaemic encephalopathy is a dramatic perinatal complication due to brain
asphyxia. Neurological and neurosensory sequelae are frequent in survivors, due to neuronal
damage and loss.
Currently, only total or partial body hypothermia can partially prevent cell loss. However,
no treatment exists to restore neuronal functions.
Cord blood stem cells are a promising treatment for the near future.
The primary objective of this study is to test the safety and feasibility of a curative
treatment with autologous cord blood stem cell in neonatal hypoxic-ischaemic encephalopathy.
The secondary objectives are to test the efficacy of this curative treatment with cell with
neurogenic potential on the prevention of neurologic sequelae, as well as to test the optimum
timing of cell preparation administration