This study evaluates the effect of inhaled furosemide on different types of breathlessness
relief in healthy volunteers. Each volunteer inhaled mists of either furosemide or a control
substance on 3 occasions per day on 2 separate days. On one day they performed one
breathlessness test which creates an 'urge to breathe' known as air hunger (AH) and the other
day they performed a breathlessness test which increases the sense of work/effort (WE) of
breathing. The study is double blinded so neither the volunteer or the research knows which
mist is being inhaled.