Program： Clinical Study of Relationship Between Granulocyte Activation, HDAC2 and Severe
Asthma Aim：The early prediction of severe asthma, early intervention on the disease, reduce
the family and the national finance.
design:This study is a single center randomized controlled trial designed by the Department
of respiratory medicine, Xijing Hospital, as the main research unit.Compare the case
group(severe asthma group and mild-and-moderate asthma group) and control group(healthy
control group) by detecting the activity of MPO、NE、MMP-9 and ECP in the peripheral blood and
the activity of HDAC2 in PBMCs of patients.
Inclusion criteria: age 18-75 years old; diagnosis of asthma was clear; informed consent was
Exclusion criteria: poor compliance; cognitive ability is low; psychiatric disorders need to
be combined with psychotropic medication.