The purpose of this pilot study is to determine the tolerability, feasibility, and
preliminary effectiveness of intranasal oxytocin administration prior to motivational
enhancement group therapy sessions on laboratory-based measures of addiction, social
connectedness, and stress responsivity in methamphetamine(meth)-using men who have sex with
men (MSM). The investigators propose a randomized, double-blind, study of intranasal oxytocin
versus placebo 40 IU prior to each of six Motivational Interviewing Group Therapy (MIGT)
sessions in 28 mixed HIV sero-status MSM initiating treatment for amphetamine use disorder.