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More info
You can access this
clinical trial
if you have
Latent Tuberculosis
and you are
between 6 and 11
years old
3
This is a trial in the final phase before the treatment is released on the market.
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The purpose

The investigators will conduct a n=5,400 Phase 3, double-blind, individually randomised placebo-controlled clinical trial of 5 years' duration in primary schools in City of Cape Town Metropolitan Municipality, Western Cape Province, Republic of South Africa. The primary objective of the trial is to determine whether a weekly oral dose of 0.25 mg (10,000 IU) vitamin D3, administered for three years, reduces risk of acquisition of latent tuberculosis infection (LTBI) in Cape Town primary schoolchildren. Statistical analysis will be performed on an intention-to-treat basis to compare acquisition of LTBI in intervention vs. control arms during three-year follow-up. The primary analysis will be logistic regression with presence/absence of LTBI at follow-up as the outcome, adjusted for a random effect of school of attendance.

Provided treatments

  • : Cholecalciferol
  • Other: Placebo

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT02880982. The sponsor of the trial is Queen Mary University of London and it is looking for 1743 volunteers for the current phase.
Official trial title:
Trial of Vitamin D Supplementation in Cape Town Primary Schoolchildren