A single-center, randomized controlled clinical trial was done to assess the periodontal
status of the individuals and the presence of red complex microorganisms (RCM) such as
Treponema denticola, Porphyromonas.gingivalis and Tannerella.forsythia in the subgingival
tissues of periodontal pockets at baseline followed by the application of mangostana gel as
an adjunct to scaling and root planing. The periodontal parameters and RCM were again
assessed at 3rd month and compared with the placebo group.