The purpose of the present study is to investigate the association between the accumulation
of advanced glycation end-products (AGE) and adverse outcomes (e.g. death) in people
receiving haemodialysis and peritoneal dialysis based in Royal Derby Hospital, as well as the
impact of a dietetic intervention on AGE accumulation. AGE will be measured non-invasively in
the skin using a technique called skin autofluorescence (SAF).
The present study will be conducted in two parts:
Study 1: this will be a prospective study where participants will be followed-up for up to
five years. The research team will measure the accumulation of AGE in the skin using a quick
(less than five minutes) and painless technique called SAF. This involves placing the forearm
on a piece of equipment that shines a light on the skin and measures the amount of light that
is reflected back. Participants will be asked to complete nutritional and quality of life
questionnaires, measurements of weight, height, arm circumference and skinfold thickness
(i.e. anthropometry), simple eyesight tests and blood tests.
Study 2: observational non-randomized proof of principle study where malnourished dialysis
participants will receive a dietitian supervised intensive nutritional support. Participants
will be followed-up for 2 years and will receive precise oral and written instructions on how
to comply with the intervention. Blood and eyesight tests, SAF measurements, anthropometry
and nutritional and quality of life assessments will be conducted.
In Studies 1 and 2, approximately two teaspoons of blood will be collected to measure AGE
levels and do some additional blood tests to help us investigate the effects of AGEs on the
body. If the participants agree, the investigators will also store some of the blood for