The main objective of this project is to demonstrate the feasability of an endomicroscopic
biomarker of efficacy of vedolizumab and adalimumab, in Ulcerative colitis (UC) by coupling
vedolizumab to a fluorescent component, FITC (Fluorescein isothiocyanate) , and adalimumab to
This project should allow the development of a biomarker of therapeutic efficacy for
vedolizumab and adalimumab that can be used in a single time-frame in vivo in humans, while
respecting manufacturing standards and Good manufacturing procedures.