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Your journey
1What's a trial
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3Review
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More info
You can access this
clinical trial
if you have
Healthy Volunteers or Endotoxemia
and you are
over 18
years old
4
The primary goal of this phase is to monitor the long-term effects.
The treatment is already on the market.
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The purpose

Defibrotide is an anti-inflammatory and anti-coagulatory agent approved for treatment of veno-occlusive disease. Although it has been in clinical use for almost 30 years, the exact mechanism of action has never been fully elucidated. Thus, the effects of defibrotide will be investigated in the human endotoxemia model in order to gather further information on its actions.

Provided treatments

  • Drug: Defibrotide
  • Drug: Placebo (0.9% sodium chloride)
  • Drug: Lipopolysaccharide
  • Drug: Placebo (0.9% sodium chloride bolus)

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT02876601. The sponsor of the trial is Bernd Jilma and it is looking for 20 volunteers for the current phase.
Official trial title:
Defibrotide in the Human Endotoxemia Model -- an Exploratory Trial Investigating the Effects and the Mechanisms of Defibrotide