The purpose of this study is to examine the effects of bile acid and bile acids sequestrants
on GLP-1 Secretion, during a meal, in patients after Roux-en-Y gastric bypass.
Drug: Chenodeoxycholic Acid
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Full eligibility criteria for NCT02876484
Ages eligible for Study
Genders eligible for Study
Accepts Healthy Volunteers
- Uncomplicated RYGB performed minimum 3 months prior to the study.
- Fasting plasma glucose < 7,0 mM, HbA1c < 48 mmol/mol 3 months after RYGB
- Fasting plasma glucose > 7,0 mM, HbA1c > 48 mmol/mol 3 months after RYGB.
- Dysregulated thyroid diseases, use of antithyroid treatment.
- Late diabetic complications as retinopathy, renal insufficiency, neuropathy or
- Complications to RYGB. Documented reactive hypoglycaemia, severe dumping (vomiting,
diarrhea, severe abdominal pain after food intake).
All locations for NCT02876484
Hvidovre University Hospital
Hvidovre, Denmark, DK-2650
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View full eligibility
Tris trial is registered with FDA with number: NCT02876484. The sponsor of the trial is Hvidovre University Hospital and it is looking for 12 volunteers for the current phase.
Official trial title: Effects of Chenodeoxycholic Acid and Colesevelam on GLP-1 Secretion, During a Meal, After Roux-en-Y Gastric Bypass
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