Vitamin K2 deficiency has been shown to be profound in hemodialysis patients. It is reflected
by high plasma levels of dephosphorylated-undercarboxylated Matrix Gla protein (dp-ucMGP) and
seems to be correlated with vascular calcifications. Vascular calcifications can be assessed
using the AC24 score on a lateral abdominal X-ray.
The aim of this study is to assess first the rate of decrease of dp-ucMGP in a hemodialysis
cohort after supplementation with vitamin K2 and the correlation between this rate of
decrease and the Aortic Calcification Severity (AC24) score. The factors associated with high
levels of dp-ucMGP will be analyzed as well.