Chemotherapy is commonly used as myeloablative conditioning treatment to prepare patients for
haematopoietic stem cell transplantation (HSCT). Chemotherapy leads to several side effects,
with gastrointestinal (GI) mucositis being one of the most frequent. Current models of GI
mucositis pathophysiology are generally silent on the role of the intestinal microbiome.
The aim of the study is to identify functional mechanisms by which the intestinal microbiome
may play a key role in the pathophysiology of GI mucositis, the investigators applied high
throughput DNA-sequencing analysis to identify microbes and microbial functions that are
modulated following chemotherapy.