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More info
You can access this
clinical trial
if you have
HIV, Diastolic Dysfunction or Myocardial Fibrosis
and you are
between 40 and 75
years old
-
This is an observational trial.
You are contributing to medical knowledge about your condition.
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The purpose

In this study, investigators plan to test two potential mechanisms contributing to diastolic dysfunction among asymptomatic persons with HIV who are on cART. The first proposed mechanism is that heightened systemic immune activation/inflammation in HIV contributes to myocardial inflammation, which in turn promotes myocardial fibrosis. The second mechanism is that ectopic fat deposition (increased visceral adiposity) in HIV relates to increased intramyocardial lipid content, which in turn contributes to diastolic dysfunction. Both HIV positive and HIV-negative participants will undergo cardiac MRI/ MRS imaging studies for evaluation of myocardial fibrosis, myocardial inflammation, and intramyocardial lipid content. Traditional markers of CVD risk, inflammatory markers/immune, hormonal markers, and markers of myocardial stretch/injury will be assessed in relation to cardiac MRI/MRS outcomes. Additionally, a small subset of participants with HIV will undergo longitudinal evaluations to assess effects of a clinically prescribed hormonal therapy on myocardial structure and function.

Provided treatments

  • Other: Cardiac MRI/MRS

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT02874703. The sponsor of the trial is Massachusetts General Hospital and it is looking for 48 volunteers for the current phase.
Official trial title:
Mechanisms of Diastolic Dysfunction Among Persons With HIV Compared With Non-HIV Control Subjects