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More info
You can access this
clinical trial
if you have
Materials Testing
and you are
between 4 and 10
years old
-
The phase for this study is not defined.
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The purpose

In this randomized clinical trial, the bio-compatibility of 2 materials used for dental restorations will be compared: glass-ionomer vs resin-based composites. Urine and saliva samples will be taken for determination of bisphenol A levels at several time points, and for analysis of the estrogenic activity using ERE-CALUX. Also buccal cells will be taken. Next, DNA extraction will be done with a commercial kit. Global alterations in DNA methylation and DNA hydroxymethylation levels will be determined using UPLC-MS/MS.

Provided treatments

  • Procedure: Dental restoration

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT02874625. The sponsor of the trial is Universitaire Ziekenhuizen Leuven and it is looking for 200 volunteers for the current phase.
Official trial title:
Randomized Clinical Trial in Children to Evaluate the Biocompatibility of Resin-based Dental Materials