In this randomized clinical trial, the bio-compatibility of 2 materials used for dental
restorations will be compared: glass-ionomer vs resin-based composites.
Urine and saliva samples will be taken for determination of bisphenol A levels at several
time points, and for analysis of the estrogenic activity using ERE-CALUX.
Also buccal cells will be taken. Next, DNA extraction will be done with a commercial kit.
Global alterations in DNA methylation and DNA hydroxymethylation levels will be determined