MySweetHeart Cohort is an observational study to assess the effect of gestational diabetes
mellitus (GDM) on early life offspring's cardiovascular health.
The primary objective is to assess the effect of GDM on the surrogate markers of
cardiovascular disease (CVD) at birth (left ventricular mass index and subclinical
atherosclerosis). The secondary objective is to assess the effect of GDM on the
cardiovascular structure and function during the fetal period and neonatal adverse
cardiovascular risk factors.
The main hypothesis is that offspring of women with GDM have a larger LVMI and a larger cIMT
at birth (primary outcomes) compared with offspring of women without GDM. Further, other
hypotheses are that offspring of women with GDM have more foetal cardiovascular alterations
and adverse neonatal cardio-metabolic risk factors (secondary outcomes) compared with
offspring of women without GDM.
My SweetHeart Cohort is linked to MySweetHeart Trial, a randomized controlled trial assessing
the effect of a multidimensional interdisciplinary lifestyle and psychosocial intervention to
improve the cardio-metabolic and mental health of women with GDM and their offspring. The
principal investigators of this trial are Prof Jardena Puder and Dr Antje Horsch from
Lausanne University Hospital.