The main objective of this study is to estimate the intrinsic diagnostic qualities of the
digital dPCR in the screening of T21 from a multicentrique sample of patients with
pregnancies at high risk of T21 (risk > 1/250).
The profit expected from this technique is to propose to the encircled women a screening more
successful than that of the screening combined(organized) of the 1st quarter, simple of
realization and in a moderate cost. We thus propose here an original alternative(alternate)
method to the exclusive, expensive and binding techniques of top-debit(-flow). The recent
technical improvements and his(her,its) advantages medical - economic allow to envisage a
reliable, strong and long-lasting use of the dPCR in clinical routine in the DPNI of T21 in
most of the laboratories. This pilot project could serve for the later development of a study
of clinical validation multicentrique of large scale(big turntable ladder).