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Influence of Gender Specific Differences of Saliva Composition on the Development of Dental Erosion - an In-situ Study (NCT02780973)

Healthy volunteers are observationally wearing an intraoral device with bovine tooth samples once for two hours. Afterwards, Calcium release from the bovine enamel and dentin samples is measured after extraoral erosion. Total protein concentration within the formed salivary pellicles on the bovine samples is determined. Further Salivary parameters (unstimulated and stimulated saliva flow rate, pH, buffer capacity, albumin and total protein content as well as concentration of inorganic calcium, phosphate and fluoride) are being measured. The aim of this study is to investigate whether gender differences in the salivary composition correlate with predisposition to erosion.
  • Other: Wearing of an intraoral device with bovine tooth samples
    Wearing of an intraoral device with bovine tooth samples
    Ages eligible for Study
    20 Years to 40 Years
    Genders eligible for Study
    Accepts Healthy Volunteers
    Accepts Healthy Volunteers
    Inclusion Criteria:
    • Healthy probands aged between 20 and 40 years who are able to give written consent
    Exclusion Criteria:
    • Non-fulfillment of the inclusion criteria
    • Smoking
    • Hyposalivation / xerostomia
    • Intake of any medication (except contraceptives in women)
    • Pregnant or lactating women
    • Known allergies to substances used in the study
    • Orthodontic treatment or malfunction which doesn't allow to wear an intraoral device

    1 locations

    Germany (1)
    • University Medical Center Göttingen, Dept. of Preventive Dentistry, Periodontology and Cariology
      Göttingen, Lower Saxony, Germany, 37075
    06 February, 2017
    07 February, 2017
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