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Effect of Remote Ischemic Preconditioning on Electrophysiological and Biomolecular Parameters in Non-valvular Paroxysmal Atrial Fibrillation: RIPPAF Study (NCT02779660)

The aim of the study is to examine the effect of RIPC on physiological parameters in non-valvular paroxysmal atrial fibrillation. Furthermore the study will provide a unique bio-date base for further analysis of molecular and genetic mechanisms responsible for observed results. The potential effect of RIPC on AF inducibility and/or prothrombotic activity might be implemented as additional treatment component to reduce AF burden and minimize thromboembolic risk. Interim Analysis will be done after 73 patients.
  • Procedure: Remote ischemic preconditioning (RIPC)
    RIPC will be induced by the application of 3 short episodes (5 minutes) of forearm ischemia by cuff sphygmomanometer inflation separated by 5 minutes of reperfusion.
    • Procedure: sham-intervention
      In the control group the cuff will be inflated for 3 times at 10 mm Hg for 5 minutes with 5-minute intervals
      Ages eligible for Study
      18 Years and older
      Genders eligible for Study
      All
      Accepts Healthy Volunteers
      No
      Inclusion Criteria:
      • planned invasive Atrial Fibrillation ablation
      Exclusion Criteria:
      • AF in ECG at Admission
      • history of AF ablation
      • age <18
      • pregnancy
      • neoplastic disorders
      • acute or systemic inflammation, autoimmune diseases
      • documented atrial flutter

      1 locations

      Germany (1)
      • Herzzentrum Leipzig
        recruiting
        Leipzig, Germany, 04289
      Status:
      recruiting
      Type:
      Interventional
      Phase:
      -
      Start:
      30 April, 2016
      Updated:
      16 August, 2017
      Participants:
      146
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