Aim: to investigate the clinical effectiveness over 12 weeks of three different biomaterials,
nano-hydroxyapatite based, in the therapy of the dental sensitivity.
Methods: The study is designed as a randomized clinical trial comparing: 1) Cavex Bite&White
ExSense, 2) Teethmate™ Desensitizer , 3) Ghimas Dentin Desensitizer. The pain experience was
generated by a cold stimulus directly to a sensitive tooth surface and assessed using the
Visual Analogue Scale (VAS). The response was recorded before the application of the
materials (PRE-1), immediately after (POST-1), at 1-week (POST-2), 4-weeks (POST-3) and
12-week controls (POST-4).