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You can access this
clinical trial
if you have
Multiple Sclerosis
and you are
between 18 and 65
years old
4
The primary goal of this phase is to monitor the long-term effects.
The treatment is already on the market.
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The purpose

Progressive multifocal leukoencephalopathy (PML) is the most feared complication when natalizumab (NTZ) is used in the treatment of relapsing multiple sclerosis (MS). The risk of PML increases after 18 months of treatment. When switching from NTZ to another disease modifying treatment (DMT) in these MS patients with an active disease, there is a high risk of inflammatory reactivation. Nonetheless, a washout period of several weeks is necessary before initiating a new DMT. The primary purpose of this protocol is to investigate the impact of high dose of oral methylprednisolone, given once a month during the washout period between NTZ and Fingolimod (FTY).

Provided treatments

  • Drug: Methylprednisolone
  • Drug: Placebo
  • Drug: natalizumab (NTZ)
  • Drug: fingolimob (FTY)
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Locations near you

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Tris trial is registered with FDA with number: NCT02769689. The sponsor of the trial is University Hospital, Clermont-Ferrand and it is looking for 56 volunteers for the current phase.
Official trial title:
Once a Month High-dose Methylprednisolone During Wash-out Period Between Natalizumab and Fingolimod Treatments in Patients With Multiple Sclerosis: a Randomised, Controlled, Double-blind Trial (NTZ2FTY)