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More info
You can access this
clinical trial
if you have
Leukemia, Myeloid, Acute or Myelodysplastic Syndromes
and you are
over 50
years old
1
2
This is a medium phase trial determining
the safety and dosage of the new treatment, as well as its efficacy.
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The purpose

PACT is a non-randomized multicentre phase I/II study to evaluate the feasibility and safety of the prophylactic administration of donor derived TCM. Patients with Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) who are planned to undergo a HLA -matched (9/10 or 10/10) allogeneic hematopoietic stem cell transplantation and who are either 50+ years old or have a high comorbidity score are included according to criteria as described below. TCM will be applied in escalating doses to a maximum of 30 patients who have received T cell depleted Human leukocyte antigen (HLA)-matched alloHSCT grafts and qualify for TCM transfer.

Provided treatments

  • Biological: TCM allogeneic humane central memory T cells, cryopreserved
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Locations near you

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Tris trial is registered with FDA with number: NCT02758223. The sponsor of the trial is Wuerzburg University Hospital and it is looking for 30 volunteers for the current phase.
Official trial title:
Prophylactic Application of Donor-derived Central Memory T Lymphocytes (TCM) After Allogeneic HSCT to Prevent Infectious Complications