Premature ovarian insufficiency (POI) is a life-changing condition that affects women in
their reproductive age. There is a lack of reports which focus on how to improve the
reproductive outcome of these women who wish to conceive spontaneously or use assisted
conception with their own oocytes. However, one could surmise that it is important to lower
gonadotropin levels into the physiological range before embarking on any treatment, even if
natural conception is the only choice for the woman/couple.