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You can access this
clinical trial
if you have
Acute on Chronic Liver Failure or Cirrhosis
and you are
over 18
years old
4
The primary goal of this phase is to monitor the long-term effects.
The treatment is already on the market.
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The purpose

Patients of acute & chronic liver failure have long been assumed to have coagulopathy & are given blood products prophylactically as well as during various interventions. But these patients rarely have spontaneous bleed except variceal bleed. Conventional coagulation parameters are insufficient to assess coagulation status of these patients because they reflect only a certain element of coagulation cascade while thromboelastography (TEG) gives a comprehensive report of hemostatic profile including platelet function. Studies using TEG have suggested that defects in prohemostatic drivers are counterbalanced by changes in antihemostatic drivers creating a rebalance in these patients. Acute on chronic failure is a entity with acute decompensation on underlying chronic liver failure. Since there is paucity of data regarding coagulation abnormalities in these patient, study is needed to assess predictability power of TEG in these patients with respect to coagulation abnormalities in patient with ALF and CLD ( cirrhosis) and healthy controls.

Provided treatments

  • Device: Thromboelastography
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Locations near you

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Tris trial is registered with FDA with number: NCT02757170. The sponsor of the trial is All India Institute of Medical Sciences, New Delhi and it is looking for 180 volunteers for the current phase.
Official trial title:
Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography