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The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery (NCT02756715)

Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx of blood flow. syndecan-1 was a marker of glycocalyx. The purpose of this study is to prove the variation of level of serum syndecan-1 between preoperative and postoperative period.
  • Drug: propofol group
    Patient will be anesthetized by using propofol infusion during operation.
    • Propofol
  • Drug: Desflurane group
    Patient will be anesthetized by using desflurane inhalation during operation.
    • Desflurane
Ages eligible for Study
20 Years and older
Genders eligible for Study
All
Accepts Healthy Volunteers
No
Inclusion Criteria:
  • patients who was planned to undergo knee surgery.
Exclusion Criteria:
  • age < 20 years old
  • history of previous cancer
  • history of previous peripheral vascular disease
  • Emergency surgery
The patients were allocated randomly to receive propofol or desflurane. Also, a total of 6ml of blood sample was obtained for total 6 times in consecutive order.

1. Preoperation (immediate before anesthesia induction)

2. Immediate before tourniquet off

3. 5 min after tourniquet off

4. PACU

5. postoperative 6 hours

6. postoperative 24 hours

Serum in blood will be obtained and level of serum cytokine will be evaluated by enzyme-linked immunosorbent assay

1 locations

Korea, Republic of (1)
  • Konkuk University Medical Center
    recruiting
    Seoul, Korea, Republic of, 143-729
Status:
unknown
Type:
Interventional
Phase:
-
Start:
31 January, 2016
Updated:
01 May, 2016
Participants:
100
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